Article
Tripolar chromosome segregation drives the association between maternal genotype at variants spanning PLK4 and aneuploidy in human preimplantation embryos.
Human molecular genetics - 15 Jul 2018
McCoy Rajiv C, Newnham Louise J, Ottolini Christian S, Hoffmann Eva R, Chatzimeletiou Katerina, Cornejo Omar E, Zhan Qiansheng, Zaninovic Nikica, Rosenwaks Zev, Petrov Dmitri A, Demko Zachary P, Sigurjonsson Styrmir, Handyside Alan H
Abstract excerpt
Aneuploidy is prevalent in human embryos and is the leading cause of pregnancy loss. Many aneuploidies arise during oogenesis, increasing with maternal age. Superimposed on these meiotic aneuploidies are frequent errors occurring during early mitotic divisions, contributing to widespread chromosomal mosaicism. Here we reanalyzed a published dataset comprising preimplantation genetic testing for aneuploidy in...
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