Article

Tripolar mitosis drives the association between maternal genotypes of <i>PLK4</i> and aneuploidy in human preimplantation embryos

2017-08-29

Abstract excerpt

Aneuploidy is prevalent in human preimplantation embryos and is the leading cause of pregnancy loss. Many aneuploidies arise during oogenesis, increasing in frequency with maternal age. Superimposed on these meiotic aneuploidies are a range of errors occurring during early mitotic divisions of the embryo, contributing to widespread chromosomal mosaicism. Here we reanalyzed a published dataset comprising preimplant...

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Literature Corpus work: 96f0ee18-8cce-55d5-bac2-49a24de73b42
DOI: 10.1101/182303

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