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A rapid pharmacogenomic assay to detect <i>NAT2</i> polymorphisms and guide isoniazid dosing for tuberculosis treatment

2021-01-20

Abstract excerpt

<h4>Rationale</h4> Standardized weight-based dose of anti-tubercular drugs contributes to a substantial incidence of toxicities, inadequate treatment response, and relapse, in part due to variable drug levels achieved. Single nucleotide polymorphisms (SNPs) in the N-acetyltransferase-2 (NAT2) gene explain the majority of interindividual pharmacokinetic variability of isoniazid (INH). However, an obstacle to implem...

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Literature Corpus work
93a8a518-1e40-505d-a689-bbf4d3f01f1d
DOI
10.1101/2021.01.17.21249995
Open publication

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A rapid pharmacogenomic assay to detect <i>NAT2</i> polymorphisms and guide isoniazid dosing for tuberculosis treatmentDOI 10.1101/2021.01.17.21249995
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