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Article

S-Nitrosoglutathione Reductase Plays Opposite Roles in SH-SY5Y Models of Parkinson's Disease and Amyotrophic Lateral Sclerosis.

Mediators of inflammation - 1 Jan 2015

Rizza Salvatore, Cirotti Claudia, Montagna Costanza, Cardaci Simone, Consales Claudia, Cozzolino Mauro, Carrì Maria Teresa, Cecconi Francesco, Filomeni Giuseppe

Abstract excerpt

Oxidative and nitrosative stresses have been reported as detrimental phenomena concurring to the onset of several neurodegenerative diseases. Here we reported that the ectopic modulation of the denitrosylating enzyme S-nitrosoglutathione reductase (GSNOR) differently impinges on the phenotype of two SH-SY5Y-based in vitro models of neurodegeneration, namely, Parkinson's disease (PD) and familial amyotrophic...

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Identifiers

PMID: 26491229
DOI: 10.1155/2015/536238
PMCID: PMC4600557

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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