Article
Tempol moderately extends survival in a hSOD1(G93A) ALS rat model by inhibiting neuronal cell loss, oxidative damage and levels of non-native hSOD1(G93A) forms.
PloS one - 1 Jan 2013
Linares Edlaine, Seixas Luciana V, dos Prazeres Janaina N, Ladd Fernando V L, Ladd Aliny A B L, Coppi Antonio A, Augusto Ohara
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive dysfunction and death of motor neurons by mechanisms that remain unclear. Evidence indicates that oxidative mechanisms contribute to ALS pathology, but classical antioxidants have not performed well in clinical trials. Cyclic nitroxides are an alternative worth exploring because they are multifunctional...
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