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Article

S-nitrosylated protein disulfide isomerase contributes to mutant SOD1 aggregates in amyotrophic lateral sclerosis.

Journal of neurochemistry - 1 Jan 2013

Chen Xueping, Zhang Xiaosha, Li Chen, Guan Teng, Shang Huifang, Cui Liying, Li Xin-Min, Kong Jiming

Abstract excerpt

A major hallmark of mutant superoxide dismutase (SOD1)-linked familial amyotrophic lateral sclerosis is SOD1-immunopositive inclusions found within motor neurons. The mechanism by which SOD1 becomes aggregated, however, remains unclear. In this study, we aimed to investigate the role of nitrosative stress and S-nitrosylation of protein disulfide isomerase (PDI) in the formation of SOD1 aggregates. Our data show...

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Identifiers

PMID: 23043510
DOI: 10.1111/jnc.12046

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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