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Article

Mitochondrial Complex I Reversible S-Nitrosation Improves Bioenergetics and Is Protective in Parkinson's Disease.

Antioxidants & redox signaling - 1 Jan 2018

Milanese Chiara, Tapias Victor, Gabriels Sylvia, Cerri Silvia, Levandis Giovanna, Blandini Fabio, Tresini Maria, Shiva Sruti, Greenamyre John Timothy, Gladwin Mark T, Mastroberardino Pier G

Abstract excerpt

AIMS: This study was designed to explore the neuroprotective potential of inorganic nitrite as a new therapeutic avenue in Parkinson's disease (PD). RESULTS: Administration of inorganic nitrite ameliorates neuropathology in phylogenetically distinct animal models of PD. Beneficial effects are not confined to prophylactic treatment and also occur if nitrite is administered when the pathogenic cascade is already...

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Identifiers

PMID: 28816057
DOI: 10.1089/ars.2017.6992
PMCID: PMC5749586

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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