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Antioxidant and Anti-Inflammatory Defense in Huntington’s Disease: Role of NRF2 and Pgc-1α and Therapeutic Strategies

2025-03-06

Abstract excerpt

Abstract: Huntington’s disease (HD) is a detrimental neurodegenerative disease caused by the expansion of a CAG triplet in the HTT gene, ending in the production of abnormal Huntingtin (Htt) protein with toxic gain-of-function. The mutant protein (mHtt) is responsible in several ways for the establishment of an intricate pathogenetic scenario in affected cells, particularly in HD neurons. Among all the HD features...

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Literature Corpus work
1775a23a-7d6c-55aa-b95b-99b375aea52d
DOI
10.20944/preprints202503.0410.v1
Open publication

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