Article
S-nitrosothiol depletion in amyotrophic lateral sclerosis.
Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2006
Schonhoff Christopher M, Matsuoka Masaaki, Tummala Hemachand, Johnson Michael A, Estevéz Alvaro G, Wu Rui, Kamaid Andrés, Ricart Karina C, Hashimoto Yuichi, Gaston Benjamin, Macdonald Timothy L, Xu Zuoshang, Mannick Joan B
Abstract excerpt
Recent data suggest that either excessive or deficient levels of protein S-nitrosylation may contribute to disease. Disruption of S-nitrosothiol (SNO) homeostasis may result not only from altered nitric oxide (NO) synthase activity but also from alterations in the activity of denitrosylases that remove NO groups. A subset of patients with familial amyotrophic lateral sclerosis (ALS) have mutations in superoxide...
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