Article

Endogenous TDP-43 mislocalization in a novel knock-in mouse model reveals DNA repair impairment, inflammation, and neuronal senescence

2024-03-20

Abstract excerpt

<title>Abstract</title> <p>TDP-43 mislocalization and aggregation are key pathological features of motor neuron diseases (MND) including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, transgenic hTDP-43 WT or ∆NLS-overexpression animal models mainly capture late-stages TDP-43 proteinopathy, and do not provide a complete understanding of early motor neuron-specific pathology during...

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Literature Corpus work: 4a678d11-9759-5b83-bf66-86ab8faf3c4d
DOI: 10.21203/rs.3.rs-3879966/v2

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