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Article

Genome instability and loss of protein homeostasis: converging paths to neurodegeneration?

Open biology - 1 Apr 2021

Ainslie Anna, Huiting Wouter, Barazzuol Lara, Bergink Steven

Abstract excerpt

Genome instability and loss of protein homeostasis are hallmark events of age-related diseases that include neurodegeneration. Several neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis are characterized by protein aggregation, while an impaired DNA damage response (DDR) as in many genetic DNA repair disorders leads to pronounced...

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Identifiers

PMID: 33878947
DOI: 10.1098/rsob.200296
PMCID: PMC8059563

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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