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Article

Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 2003

Donaldson Kathryn M, Li Wei, Ching Keith A, Batalov Serge, Tsai Chih-Cheng, Joazeiro Claudio A P

Abstract excerpt

A hallmark of most neurodegenerative diseases, including those caused by polyglutamine expansion, is the formation of ubiquitin (Ub)-positive protein aggregates in affected neurons. This finding suggests that the Ub system may be involved in common mechanisms underlying these otherwise unrelated...

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Identifiers

PMID: 12857950
DOI: 10.1073/pnas.1530212100
PMCID: PMC166409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12857950-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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