Article
Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 2003
Donaldson Kathryn M, Li Wei, Ching Keith A, Batalov Serge, Tsai Chih-Cheng, Joazeiro Claudio A P
Abstract excerpt
A hallmark of most neurodegenerative diseases, including those caused by polyglutamine expansion, is the formation of ubiquitin (Ub)-positive protein aggregates in affected neurons. This finding suggests that the Ub system may be involved in common mechanisms underlying these otherwise unrelated diseases. Here we report the finding of ataxin-3 (Atx-3), whose mutation is implicated in the neurodegenerative disease...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.