Article
Genomic expression catalogue of a global collection of BCG vaccine strains show evidence for highly diverged metabolic and cell-wall adaptations.
Scientific reports - 21 Oct 2015
Abdallah Abdallah M, Hill-Cawthorne Grant A, Otto Thomas D, Coll Francesc, Guerra-Assunção José Afonso, Gao Ge, Naeem Raeece, Ansari Hifzur, Malas Tareq B, Adroub Sabir A, Verboom Theo, Ummels Roy, Zhang Huoming, Panigrahi Aswini Kumar, McNerney Ruth, Brosch Roland, Clark Taane G, Behr Marcel A, Bitter Wilbert, Pain Arnab
Abstract excerpt
Although Bacillus Calmette-Guérin (BCG) vaccines against tuberculosis have been available for more than 90 years, their effectiveness has been hindered by variable protective efficacy and a lack of lasting memory responses. One factor contributing to this variability may be the diversity of the BCG strains that are used around the world, in part from genomic changes accumulated during vaccine production and their...
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