Article
Genome plasticity of BCG and impact on vaccine efficacy.
Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2007
Brosch Roland, Gordon Stephen V, Garnier Thierry, Eiglmeier Karin, Frigui Wafa, Valenti Philippe, Dos Santos Sandrine, Duthoy Stéphanie, Lacroix Céline, Garcia-Pelayo Carmen, Inwald Jacqueline K, Golby Paul, Garcia Javier Nuñez, Hewinson R Glyn, Behr Marcel A, Quail Michael A, Churcher Carol, Barrell Bart G, Parkhill Julian, Cole Stewart T
Abstract excerpt
To understand the evolution, attenuation, and variable protective efficacy of bacillus Calmette-Guérin (BCG) vaccines, Mycobacterium bovis BCG Pasteur 1173P2 has been subjected to comparative genome and transcriptome analysis. The 4,374,522-bp genome contains 3,954 protein-coding genes, 58 of which are present in two copies as a result of two independent tandem duplications, DU1 and DU2. DU1 is restricted to BCG...
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