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Mapping Gene-by-Gene Single-Nucleotide Variation in 8,535 Mycobacterium tuberculosis Genomes: a Resource To Support Potential Vaccine and Drug Development.

mSphere - 10 Mar 2021

Papakonstantinou Danai, Dunn Steven J, Draper Simon J, Cunningham Adam F, O'Shea Matthew K, McNally Alan

Abstract excerpt

Tuberculosis (TB) is responsible for millions of deaths annually. More effective vaccines and new antituberculous drugs are essential to control the disease. Numerous genomic studies have advanced our knowledge about M. tuberculosis drug resistance, population structure, and transmission patterns. At the same time, reverse vaccinology and drug discovery pipelines have identified potential immunogenic vaccine...

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Identifiers

PMID: 33692198
DOI: 10.1128/mSphere.01224-20
PMCID: PMC8546714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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