Article
Evolution and Strain Variation in BCG.
Advances in experimental medicine and biology - 1 Jan 2017
Abdallah Abdallah M, Behr Marcel A
Abstract excerpt
BCG vaccines were derived by in vitro passage, during the years 1908-1921, at the Pasteur Institute of Lille. Following the distribution of stocks of BCG to vaccine production laboratories around the world, it was only a few decades before different BCG producers recognized that there were variants of BCG, likely due to different passaging conditions in the different laboratories. This ultimately led to the...
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