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Article

Novel genome polymorphisms in BCG vaccine strains and impact on efficacy.

BMC genomics - 15 Sept 2008

Leung Andrea S, Tran Vanessa, Wu Zuowei, Yu Xuping, Alexander David C, Gao George Fu, Zhu Baoli, Liu Jun

Abstract excerpt

Bacille Calmette-Guérin (BCG) is an attenuated strain of Mycobacterium bovis currently used as a vaccine against tuberculosis. Global distribution and propagation of BCG has contributed to the in vitro evolution of the vaccine strain and is thought to partially account for the different outcomes of BCG vaccine trials. Previous efforts by several molecular techniques effectively identified large sequence...

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Identifiers

PMID: 18793412
DOI: 10.1186/1471-2164-9-413
PMCID: PMC2553098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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