A comprehensive survey of single nucleotide polymorphisms (SNPs) across Mycobacterium bovis strains and M. bovis BCG vaccine strains refines the genealogy and defines a minimal set of SNPs that separate virulent M. bovis strains and M. bovis BCG strains.

doi:10.1128/IAI.01099-08

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A comprehensive survey of single nucleotide polymorphisms (SNPs) across Mycobacterium bovis strains and M. bovis BCG vaccine strains refines the genealogy and defines a minimal set of SNPs that separate virulent M. bovis strains and M. bovis BCG strains.

Infection and immunity - 1 May 2009

Garcia Pelayo M Carmen, Uplekar Swapna, Keniry Andrew, Mendoza Lopez Pablo, Garnier Thierry, Nunez Garcia Javier, Boschiroli Laura, Zhou Xiangmei, Parkhill Julian, Smith Noel, Hewinson R Glyn, Cole Stewart T, Gordon Stephen V

Abstract excerpt

To further unravel the mechanisms responsible for attenuation of the tuberculosis vaccine Mycobacterium bovis BCG, comparative genomics was used to identify single nucleotide polymorphisms (SNPs) that differed between sequenced strains of Mycobacterium bovis and M. bovis BCG. SNPs were assayed in M. bovis isolates from France and the United Kingdom and from different BCG vaccines in order to identify those that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BCG Vaccine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Fingerprinting

Share to France

Share to Genome, Bacterial

Share to Mycobacterium bovis

Share to Point Mutation

Share to United Kingdom

Share to Vaccines, Attenuated

Source

Open in PubMed Open full text

Identifiers

PMID: 19289514
DOI: 10.1128/IAI.01099-08
PMCID: PMC2681724

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A comprehensive survey of single nucleotide polymorphisms (SNPs) across Mycobacterium bovis strains and M. bovis BCG vaccine strains refines the genealogy and defines a minimal set of SNPs that separate virulent M. bovis strains and M. bovis BCG strains.PMID 19289514Read ↗

Mapping Gene-by-Gene Single-Nucleotide Variation in 8,535 Mycobacterium tuberculosis Genomes: a Resource To Support Potential Vaccine and Drug Development.Semantic proximity Read ↗

Whole-genome sequences of four Mycobacterium bovis BCG vaccine strains.Semantic proximity Read ↗

Genomic expression catalogue of a global collection of BCG vaccine strains show evidence for highly diverged metabolic and cell-wall adaptations.Semantic proximity Read ↗

Genome Sequencing and Analysis of BCG Vaccine StrainsSemantic proximity Read ↗

Genomic characteristics of two most widely used BCG vaccine strains: Danish 1331 and Pasteur 1173P2Semantic proximity Read ↗

Comparative genomics of BCG vaccines.Semantic proximity Read ↗

A robust SNP barcode for typing Mycobacterium tuberculosis complex strains.Semantic proximity Read ↗

Comparative Genomics of Field Isolates of Mycobacterium bovis and M. caprae Provides Evidence for Possible Correlates with Bacterial Viability and VirulenceSemantic proximity Read ↗

Single nucleotide polymorphisms in the Mycobacterium bovis genome resolve phylogenetic relationships.Semantic proximity Read ↗

Characterization of the transcriptional regulator Rv3124 of Mycobacterium tuberculosis identifies it as a positive regulator of molybdopterin biosynthesis and defines the functional consequences of a non-synonymous SNP in the Mycobacterium bovis BCG orthologue.Semantic proximity Read ↗

A revised SNP-based barcoding scheme for typing Mycobacterium tuberculosis complex isolates.Semantic proximity Read ↗

Comprehensive analysis of Mycobacterium tuberculosis genomes reveals genetic variations in bacterial virulence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.