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Article

Genetic diversity of clinical Mycobacterium bovis BCG isolates from an immunocompromised patient with BCG infection.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Oct 2026

Sawaswong Vorthon, Premchaiporn Pornpimol, Wongjarit Kanphai, Prammananan Therdsak, Petsong Suthidee, Srichomthong Chalurmpon, Anugulruengkitt Suvaporn, Payungporn Sunchai, Shotelersuk Vorasuk, Rotcheewaphan Suwatchareeporn

Abstract excerpt

BACKGROUND: The Bacillus Calmette-Guérin (BCG) vaccine is widely administered to prevent severe tuberculosis but can cause serious adverse events, including disseminated BCGosis, in immunocompromised individuals. However, studies investigating the in vivo genetic adaptation and microevolution of this live-attenuated vaccine during prolonged infection remain limited. METHODS: Two clinical Mycobacterium bovis BCG...

Read the complete abstract on PubMed

Topics

Humans
Mycobacterium bovis
Immunocompromised Host
BCG Vaccine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Phylogeny

Genetic Variation

Tuberculosis

Whole Genome Sequencing

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 42641843
DOI: 10.1016/j.meegid.2026.106014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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