Article
Comparative genomics of BCG vaccines by whole-genome DNA microarray.
Science (New York, N.Y.) - 28 May 1999
Behr M A, Wilson M A, Gill W P, Salamon H, Schoolnik G K, Rane S, Small P M
Abstract excerpt
Bacille Calmette-Guérin (BCG) vaccines are live attenuated strains of Mycobacterium bovis administered to prevent tuberculosis. To better understand the differences between M. tuberculosis, M. bovis, and the various BCG daughter strains, their genomic compositions were studied by performing comparative hybridization experiments on a DNA microarray. Regions deleted from BCG vaccines relative to the virulent M....
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