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Article

Genetic and immunologic determinants of BCG disease: from mechanism to prevention.

Annals of medicine - 1 Dec 2026

Chen Feng, Shen Yifan, Yan Qianhui, Zheng Daishan, Chen Xiaoli, Fang Longyu, Sun Mengchen, Zhang Yuansi, Chu Maoping, Yang Enhui, Huang Xiu-Feng

Abstract excerpt

BACKGROUND: Bacillus Calmette-Guérin (BCG) infection, a disseminated infection triggered in immunocompromised hosts by the administration of the attenuated BCG vaccine, is characterized by a pathogenic mechanism that involves the synergistic interaction between host immune deficiencies and strain-specific genetic mutations. METHODS: This review synthesizes published multi-omics and proteomics findings from the...

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Antitubercular Agents
BCG Vaccine
Drug Resistance, Bacterial
Immunocompromised Host
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mycobacterium bovis

Mycobacterium tuberculosis

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Identifiers

PMID: 41770622
DOI: 10.1080/07853890.2026.2634548
PMCID: PMC12954803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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