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Article

Clinical validation of a multipurpose assay for detection and genotyping of CALR mutations in myeloproliferative neoplasms.

American journal of clinical pathology - 1 Nov 2015

Mehrotra Meenakshi, Luthra Rajyalakshmi, Singh Rajesh R, Barkoh Bedia A, Galbincea John, Mehta Pramod, Goswami Rashmi S, Jabbar Kausar J, Loghavi Sanam, Medeiros L Jeffrey, Verstovsek Srdan, Patel Keyur P

Abstract excerpt

OBJECTIVES: To develop a polymerase chain reaction (PCR)-based approach to detect CALR mutations in myeloproliferative neoplasms (MPNs) in a clinical laboratory. METHODS: DNA was extracted from bone marrow aspirate samples of 67 JAK2 wild-type MPNs (22 with matched peripheral blood), 54 cases of unclassifiable myelodysplastic syndrome/MPN, and 16 cases of atypical chronic myeloid leukemia. We used genomic DNA to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26486739
DOI: 10.1309/AJCP5LA2LDDNQNNC

Genes

CALR
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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