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Article

Molecular testing for JAK2, MPL, and CALR in myeloproliferative neoplasms.

American journal of hematology - 1 Dec 2016

Xia Daniel, Hasserjian Robert P

Abstract excerpt

Polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) are myeloproliferative neoplasms characterized by recurrent somatic mutations in JAK2, CALR, and MPL. This short review addresses (1) the spectrum of mutations seen in PV, ET, and PMF, (2) the emerging genotype-phenotype correlations, (3) the current role of molecular testing in disease classification and management, and (4)...

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Topics

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Share to Calreticulin
Share to CALR gene
Share to Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Janus Kinase 2

Share to Molecular Diagnostic Techniques

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Share to Myeloproliferative Disorders

Share to Receptors, Thrombopoietin

Source

Identifiers

PMID: 27727468
DOI: 10.1002/ajh.24578

Genes

CALR
JAK2
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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