Article
Quantitative assessment of JAK2 V617F and CALR mutations in Philadelphia negative myeloproliferative neoplasms.
Leukemia research - 1 Feb 2018
Gángó Ambrus, Mózes Réka, Boha Zsófia, Kajtár Béla, Timár Botond, Király Péter Attila, Kiss Richárd, Fésüs Viktória, Nagy Noémi, Demeter Judit, Körösmezey Gábor, Borbényi Zita, Marton Imelda, Szőke Anita, Masszi Tamás, Farkas Péter, Várkonyi Judit, Plander Márk, Pósfai Éva, Egyed Miklós, Pál Katalin, Radványi Gáspár, Hamed Aryan, Csomor Judit, Matolcsy András, Alpár Donát, Bödör Csaba
Abstract excerpt
BACKGROUND: Philadelphia negative myeloproliferative neoplasms (MPNs) are characterized by frequent mutations of driver genes including JAK2, CALR and MPL. While the influence of JAK2 V617F mutant allele burden on the clinical phenotype of MPN patients is well-described, the impact of CALR mutant allele burden on clinical features needs further investigation. PATIENTS AND METHODS: Quantitative assessment of JAK2...
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