Article
Pitfalls in CALR exon 9 mutation detection: A single-center experience in 571 positive patients.
International journal of laboratory hematology - 1 Dec 2020
Verger Emmanuelle, Maslah Nabih, Schlageter Marie-Helene, Chomienne Christine, Kiladjian Jean-Jacques, Giraudier Stephane, Cassinat Bruno
Abstract excerpt
INTRODUCTION: The pathogenesis of myeloproliferative neoplasms (MPNs) is closely related to the acquisition of specific molecular alterations in JAK2, MPL, or CALR genes, the presence of which represent major diagnostic criteria in the WHO classification. The CALR exon 9 insertions and deletions are very heterogeneous, and their detection mainly relies on polymerase chain reaction (PCR) fragment length analysis....
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