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Article

A Novel Human scFv Library with Non-Combinatorial Synthetic CDR Diversity.

PloS one - 1 Jan 2015

Bai Xuelian, Kim Jihye, Kang Seungmin, Kim Wankyu, Shim Hyunbo

Abstract excerpt

The present work describes the construction and validation of a human scFv library with a novel design approach to synthetic complementarity determining region (CDR) diversification. The advantage of synthetic antibody libraries includes the possibility of exerting fine control over factors like framework sequences, amino acid and codon usage, and CDR diversity. However, random combinatorial synthesis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26484868
DOI: 10.1371/journal.pone.0141045
PMCID: PMC4613135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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