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Construction of a Large Synthetic Human scFv Library with Six Diversified CDRs and High Functional Diversity

1 Feb 2009

Abstract excerpt

Antibody phage display provides a powerful and efficient tool for the discovery and development of monoclonal antibodies for therapeutic and other applications. Antibody clones from synthetic libraries with optimized design features have several distinct advantages that include high stability, high levels of expression, and ease of downstream optimization and engineering. In this study, a fully synthetic human...

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PMID: 19277506
DOI: 10.1007/s10059-009-0028-9

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