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Article

Synthetic antibodies designed on natural sequence landscapes.

Journal of molecular biology - 9 Sept 2011

Zhai Wenwu, Glanville Jacob, Fuhrmann Markus, Mei Li, Ni Irene, Sundar Purnima D, Van Blarcom Thomas, Abdiche Yasmina, Lindquist Kevin, Strohner Ralf, Telman Dilduz, Cappuccilli Guido, Finlay William J J, Van den Brulle Jan, Cox David R, Pons Jaume, Rajpal Arvind

Abstract excerpt

We present a method for synthetic antibody library generation that combines the use of high-throughput immune repertoire analysis and a novel synthetic technology. The library design recapitulates positional amino acid frequencies observed in natural antibody repertoires. V-segment diversity in four heavy (V(H)) and two kappa (V(κ)) germlines was introduced based on the analysis of somatically hypermutated...

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Identifiers

PMID: 21787786
DOI: 10.1016/j.jmb.2011.07.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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