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A fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties

25 Mar 2013

Abstract excerpt

This report describes the design, generation and testing of Ylanthia, a fully synthetic human Fab antibody library with 1.3E+11 clones. Ylanthia comprises 36 fixed immunoglobulin (Ig) variable heavy (VH)/variable light (VL) chain pairs, which cover a broad range of canonical complementarity-determining region (CDR) structures. The variable Ig heavy and Ig light (VH/VL) chain pairs were selected for biophysical...

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PMID: 23571156
DOI: 10.4161/mabs.24218

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