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Article

HuCAL PLATINUM, a synthetic Fab library optimized for sequence diversity and superior performance in mammalian expression systems.

Journal of molecular biology - 14 Oct 2011

Prassler Josef, Thiel Stefanie, Pracht Catrin, Polzer Andrea, Peters Solveig, Bauer Marion, Nörenberg Stephanie, Stark Yvonne, Kölln Johanna, Popp Andreas, Urlinger Stefanie, Enzelberger Markus

Abstract excerpt

This article describes the design of HuCAL (human combinatorial antibody library) PLATINUM, an optimized, second-generation, synthetic human Fab antibody library with six trinucleotide-randomized complementarity-determining regions (CDRs). Major improvements regarding the optimized antibody library sequence space were implemented. Sequence space optimization is considered a multistep process that includes the...

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Identifiers

PMID: 21856311
DOI: 10.1016/j.jmb.2011.08.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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