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Article

A universal combinatorial design of antibody framework to graft distinct CDR sequences: a bioinformatics approach.

Proteins - 1 Mar 2012

Haidar Jaafar N, Yuan Qing-An, Zeng Lin, Snavely Mark, Luna Xenia, Zhang Haifan, Zhu Wei, Ludwig Dale L, Zhu Zhenping

Abstract excerpt

Antibody (Ab) humanization is crucial to generate clinically relevant biologics from hybridoma-derived monoclonal antibodies (mAbs). In this study, we integrated antibody structural information from the Protein Data Bank with known back-to-mouse mutational data to build a universal consensus of framework positions (10 heavy and 7 light) critical for the preservation of the functional conformation of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22180101
DOI: 10.1002/prot.23246

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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