Article
Microtubule-bundling activity of the centrosomal protein, Cep169, and its binding to microtubules.
Biochemical and biophysical research communications - 27 Nov 2015
Mori Yusuke, Taniyama Yuki, Tanaka Sayori, Fukuchi Hiroki, Terada Yasuhiko
Abstract excerpt
CDK5RAP2 is a centrosomal protein that regulates the recruitment of a γ-tubulin ring complex (γ-TuRC) onto centrosomes and microtubules (MTs) dynamics as a member of MT plus-end-tracking proteins (+TIPs). In our previous report, we found mammalian Cep169 as a CDK5RAP2 binding partner, and Cep169 accumulates at the distal ends of MTs and centrosomes, and coincides with CDK5RAP2. Depletion of Cep169 induces MT...
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