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Article

Interaction of CDK5RAP2 with EB1 to track growing microtubule tips and to regulate microtubule dynamics.

Molecular biology of the cell - 1 Aug 2009

Fong Ka-Wing, Hau Shiu-Yeung, Kho Yik-Shing, Jia Yue, He Lisheng, Qi Robert Z

Abstract excerpt

Mutations in cdk5rap2 are linked to autosomal recessive primary microcephaly, and attention has been paid to its function at centrosomes. In this report, we demonstrate that CDK5RAP2 localizes to microtubules and concentrates at the distal tips in addition to centrosomal localization. CDK5RAP2 interacts directly with EB1, a prototypic member of microtubule plus-end tracking proteins, and contains the basic and...

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Identifiers

PMID: 19553473
DOI: 10.1091/mbc.e09-01-0009
PMCID: PMC2777926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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