Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A CEP215-HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer.

Nature communications - 18 Mar 2016

Chavali Pavithra L, Chandrasekaran Gayathri, Barr Alexis R, Tátrai Péter, Taylor Chris, Papachristou Evaggelia K, Woods C Geoffrey, Chavali Sreenivas, Gergely Fanni

Abstract excerpt

Numerical centrosome aberrations underlie certain developmental abnormalities and may promote cancer. A cell maintains normal centrosome numbers by coupling centrosome duplication with segregation, which is achieved through sustained association of each centrosome with a mitotic spindle pole. Although the microcephaly- and primordial dwarfism-linked centrosomal protein CEP215 has been implicated in this process,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Centrosome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chickens

Share to Cluster Analysis

Share to Intracellular Signaling Peptides and Proteins

Share to Kinesins

Share to Nerve Tissue Proteins

Share to Protein Interaction Maps

Source

Open in PubMed Open full text

Identifiers

PMID: 26987684
DOI: 10.1038/ncomms11005
PMCID: PMC4802056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A CEP215-HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer.PMID 26987684Read ↗

HSET overexpression fuels tumor progression via centrosome clustering-independent mechanisms in breast cancer patientsSemantic proximity Read ↗

Less is More: Nek2A Unclusters Extra Centrosomes and Induces Cell Death in Cancer Cells via KIF2C InteractionSemantic proximity Read ↗

Human microcephaly ASPM protein is a spindle pole-focusing factor that functions redundantly with CDK5RAP2Semantic proximity Read ↗

TRIM37 recognizes a bipartite degron to ubiquitinate centrosome substratesSemantic proximity Read ↗

Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.Semantic proximity Read ↗

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.Semantic proximity Read ↗

Oncogenes and tumour suppressors take on centrosomes.Semantic proximity Read ↗

Origins and consequences of centrosome aberrations in human cancersSemantic proximity Read ↗

TRIM37: a critical orchestrator of centrosome functionSemantic proximity Read ↗

PLK4 homodimerization is required for CEP152 centrosome localization and spindle organizationSemantic proximity Read ↗

Cep192 insufficiency underlies haploid instability in human cellsSemantic proximity Read ↗

Cep192 insufficiency underlies haploid instability in human cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.