Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fission yeast Alp14 is a dose-dependent plus end-tracking microtubule polymerase.

Molecular biology of the cell - 1 Aug 2012

Al-Bassam Jawdat, Kim Hwajin, Flor-Parra Ignacio, Lal Neeraj, Velji Hamida, Chang Fred

Abstract excerpt

XMAP215/Dis1 proteins are conserved tubulin-binding TOG-domain proteins that regulate microtubule (MT) plus-end dynamics. Here we show that Alp14, a XMAP215 orthologue in fission yeast, Schizosaccharomyces pombe, has properties of a MT polymerase. In vivo, Alp14 localizes to growing MT plus ends in a manner independent of Mal3 (EB1). alp14-null mutants display short interphase MTs with twofold slower assembly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Interphase
Share to Microtubule-Associated Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microtubules

Share to Protein Binding

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Share to Spindle Apparatus

Share to Tubulin

Source

Open in PubMed Open full text

Identifiers

PMID: 22696680
DOI: 10.1091/mbc.E12-03-0205
PMCID: PMC3408415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fission yeast Alp14 is a dose-dependent plus end-tracking microtubule polymerase.PMID 22696680Read ↗

Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint.Semantic proximity Read ↗

The interaction of TOGp with microtubules and tubulin.Semantic proximity Read ↗

Effects of {gamma}-tubulin complex proteins on microtubule nucleation and catastrophe in fission yeast.Semantic proximity Read ↗

TOG-tubulin binding specificity promotes microtubule dynamics and mitotic spindle formation.Semantic proximity Read ↗

CLASP regulates mitochondrial distribution in Schizosaccharomyces pombe.Semantic proximity Read ↗

Role of nucleocytoplasmic transport in interphase microtubule organization in fission yeast.Semantic proximity Read ↗

An isolated CLASP TOG domain suppresses microtubule catastrophe and promotes rescue.Semantic proximity Read ↗

Targeted movement of cell end factors in fission yeast.Semantic proximity Read ↗

Modulation of Alp4 function in Schizosaccharomyces pombe induces novel phenotypes that imply distinct functions for nuclear and cytoplasmic gamma-tubulin complexes.Semantic proximity Read ↗

A non-ring-like form of the Dam1 complex modulates microtubule dynamics in fission yeast.Semantic proximity Read ↗

Interdependency of fission yeast Alp14/TOG and coiled coil protein Alp7 in microtubule localization and bipolar spindle formation.Semantic proximity Read ↗

Human EML4, a novel member of the EMAP family, is essential for microtubule formationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.