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Article

Tubulin chaperone E binds microtubules and proteasomes and protects against misfolded protein stress.

Cellular and molecular life sciences : CMLS - 1 Jun 2010

Voloshin Olga, Gocheva Yana, Gutnick Marina, Movshovich Natalia, Bakhrat Anya, Baranes-Bachar Keren, Bar-Zvi Dudy, Parvari Ruti, Gheber Larisa, Raveh Dina

Abstract excerpt

Mutation of tubulin chaperone E (TBCE) underlies hypoparathyroidism, retardation, and dysmorphism (HRD) syndrome with defective microtubule (MT) cytoskeleton. TBCE/yeast Pac2 comprises CAP-Gly, LRR (leucine-rich region), and UbL (ubiquitin-like) domains. TBCE folds alpha-tubulin and promotes alpha/beta dimerization. We show that Pac2 functions in MT dynamics: the CAP-Gly domain binds alpha-tubulin and MTs, and...

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Source

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Identifiers

PMID: 20204449
DOI: 10.1007/s00018-010-0308-8
PMCID: PMC11115895

Genes

TBCE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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