Article

TRIM37 recognizes a bipartite degron to ubiquitinate centrosome substrates

2025-12-21

Abstract excerpt

Dysregulation of the E3 ubiquitin ligase TRIM37 is associated with tumor formation and Mulibrey nanism, a recessive developmental syndrome. TRIM37 regulates steady-state levels of centrosome proteins and limits their ectopic assembly, but how it recognizes and ubiquitinates its substrates is poorly understood. We found that TRIM37 directly ubiquitinates the centrosome-forming protein Cep192 at 7 lysines clustered...

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Identifiers and source

Literature Corpus work: 7a140372-fa7d-575f-acbd-43f86b4c3eb7
DOI: 10.64898/2025.12.19.695442

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