Article
Comparison of the mutational spectra of the lacZ transgene in four organs of the MutaMouse treated with benzo[a]pyrene: target organ specificity.
Mutation research - 14 Feb 2000
Hakura A, Tsutsui Y, Sonoda J, Tsukidate K, Mikami T, Sagami F
Abstract excerpt
We recently demonstrated that not all organs with a high rate of induction of mutation in the lacZ transgene develop tumors in the lambdalacZ transgenic mice (MutaMouse) used for a long-term carcinogenicity study with benzo[a]pyrene (BP). To better understand the role of chemical-induced in vivo mutations in carcinogenesis, we compared the mutational spectra of the lacZ transgene in four organs of the MutaMouse...
Topics
- Administration, Oral
- Amino Acid Substitution
- Animals
- Bacteriophages
- Base Sequence
- Benzo(a)pyrene
- Colon
- DNA
- DNA Mutational Analysis
- Gastric Mucosa
- Lac Operon
- Male
- Mice
- Mice, Inbred BALB C