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Krüppel-like Factor-4-Mediated Macrophage Polarization and Phenotypic Transitions Drive Intestinal Fibrosis in THP-1 Monocyte Models In Vitro.

Medicina (Kaunas, Lithuania) - 26 Apr 2024

Kanno Takuya, Katano Takahito, Shimura Takaya, Tanaka Mamoru, Nishie Hirotada, Fukusada Shigeki, Ozeki Keiji, Ogawa Isamu, Iwao Takahiro, Matsunaga Tamihide, Kataoka Hiromi

Abstract excerpt

Background and Objectives: Despite the fact that biologic drugs have transformed inflammatory bowel disease (IBD) treatment, addressing fibrosis-related strictures remains a research gap. This study explored the roles of cytokines, macrophages, and Krüppel-like factors (KLFs), specifically KLF4, in intestinal fibrosis, as well as the interplay of KLF4 with various gut components. Materials and Methods: This study...

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Identifiers

PMID: 38792896
DOI: 10.3390/medicina60050713
PMCID: PMC11122781

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