Article

SMAD4 suppresses colitis-associated carcinoma through inhibition of CCL20/CCR6-mediated inflammation

2022-05-25

Abstract excerpt

<h4>Background & Aims</h4> Chronic inflammation in the colon is a predisposing factor for colon cancer. We previously reported that colon epithelial cell silencing of Smad4 , the central downstream mediator of TGFβ family signaling, increased epithelial expression of inflammatory genes, including the chemokine CCL20, and increased susceptibility to colitis-associated cancer. Here, we examine the role of the chem...

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Literature Corpus work: 5f298bc9-6ce2-5c48-a6ac-635325773953
DOI: 10.1101/2022.05.25.492945

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