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Article

Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages.

The Journal of biological chemistry - 18 Nov 2005

Feinberg Mark W, Cao Zhuoxiao, Wara Akm Khyrul, Lebedeva Maria A, Senbanerjee Sucharita, Jain Mukesh K

Abstract excerpt

Activation of macrophages is important in chronic inflammatory disease states such as atherosclerosis. Proinflammatory cytokines such as interferon-gamma (IFN-gamma), lipopolysaccharide (LPS), or tumor necrosis factor-alpha can promote macrophage activation. Conversely, anti-inflammatory factors such as transforming growth factor-beta1 (TGF-beta1) can decrease proinflammatory activation. The molecular mediators...

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Source

Identifiers

PMID: 16169848
DOI: 10.1074/jbc.M509378200

Genes

KLF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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