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Article

Perturbations of PIP3 signalling trigger a global remodelling of mRNA landscape and reveal a transcriptional feedback loop.

Nucleic acids research - 16 Nov 2015

Kiselev Vladimir Yu, Juvin Veronique, Malek Mouhannad, Luscombe Nicholas, Hawkins Phillip, Le Novère Nicolas, Stephens Len

Abstract excerpt

PIP3 is synthesized by the Class I PI3Ks and regulates complex cell responses, such as growth and migration. Signals that drive long-term reshaping of cell phenotypes are difficult to resolve because of complex feedback networks that operate over extended times. PIP3-dependent modulation of mRNA accumulation is clearly important in this process but is poorly understood. We have quantified the genome-wide...

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Identifiers

PMID: 26464442
DOI: 10.1093/nar/gkv1015
PMCID: PMC4787766

Genes

EGF
PRDM1
PTEN
SRF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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