Article

Nuclear upregulation of PI3K p110β correlates with increased rRNA transcription in endometrial cancer cells

2019-12-20

Abstract excerpt

Genes encoding for components of the phosphoinositide 3-kinase (PI3K) pathway are frequently mutated in cancer, including inactivating mutations of PTEN and activating mutations of PIK3CA , encoding the PI3K catalytic subunit p110α. PIK3CB , encoding p110β, is rarely mutated, but can contribute to tumourigenesis in some PTEN-deficient tumours. The underlying molecular mechanisms are however poorly understood. B...

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Literature Corpus work: baa6650a-7223-5803-9ab0-167278bbfc4e
DOI: 10.1101/2019.12.20.884122

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