Article
The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors.
Nature cell biology - 1 Mar 2017
Lin Aifu, Hu Qingsong, Li Chunlai, Xing Zhen, Ma Guolin, Wang Cheng, Li Jun, Ye Yin, Yao Jun, Liang Ke, Wang Shouyu, Park Peter K, Marks Jeffrey R, Zhou Yan, Zhou Jianwei, Hung Mien-Chie, Liang Han, Hu Zhibin, Shen Hongbing, Hawke David H, Han Leng, Zhou Yubin, Lin Chunru, Yang Liuqing
Abstract excerpt
Phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3 or PIP3) mediates signalling pathways as a second messenger in response to extracellular signals. Although primordial functions of phospholipids and RNAs have been hypothesized in the 'RNA world', physiological RNA-phospholipid interactions and their involvement in essential cellular processes have remained a mystery. We explicate the contribution of...
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