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Article

Active PI3K pathway causes an invasive phenotype which can be reversed or promoted by blocking the pathway at divergent nodes.

PloS one - 1 Jan 2012

Wallin Jeffrey J, Guan Jane, Edgar Kyle A, Zhou Wei, Francis Ross, Torres Anthony C, Haverty Peter M, Eastham-Anderson Jeffrey, Arena Sabrina, Bardelli Alberto, Griffin Sue, Goodall John E, Grimshaw Kyla M, Hoeflich Klaus P, Torrance Christopher, Belvin Marcia, Friedman Lori S

Abstract excerpt

The PTEN/PI3K pathway is commonly mutated in cancer and therefore represents an attractive target for therapeutic intervention. To investigate the primary phenotypes mediated by increased pathway signaling in a clean, patient-relevant context, an activating PIK3CA mutation (H1047R) was knocked-in...

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Share to Class I Phosphatidylinositol 3-Kinases
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22570710
DOI: 10.1371/journal.pone.0036402
PMCID: PMC3343052

Genes

PTEN
PIP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22570710-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Active PI3K pathway causes an invasive phenotype which can be reversed or promoted by blocking the pathway at divergent nodes.PMID 22570710Read ↗

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