Article
Phosphorylation at Connexin43 Serine-368 Is Necessary for Myocardial Conduction During Metabolic Stress.
Journal of cardiovascular electrophysiology - 1 Jan 2016
Nassal Michelle M J, Werdich Andreas A, Wan Xiaoping, Hoshi Malcolm, Deschênes Isabelle, Rosenbaum David S, Donahue J Kevin
Abstract excerpt
Connexin43 (Cx43) phosphorylation alters gap junction localization and function. In particular, phosphorylation at serine-368 (S368) has been suggested to alter gap junctional conductance, but previous reports have shown inconsistent results for both timing and functional effects of S368 phosphorylation. The objective of this study was to determine the functional effects of isolated S368 phosphorylation. We...
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