Article
Reduction in number of sarcolemmal KATP channels slows cardiac action potential duration shortening under hypoxia.
Biochemical and biophysical research communications - 2 Dec 2011
Zhu Zhiyong, Burnett Colin M-L, Maksymov Gennadiy, Stepniak Elizabeth, Sierra Ana, Subbotina Ekaterina, Anderson Mark E, Coetzee William A, Hodgson-Zingman Denice M, Zingman Leonid V
Abstract excerpt
The cardiovascular system operates under demands ranging from conditions of rest to extreme stress. One mechanism of cardiac stress tolerance is action potential duration shortening driven by ATP-sensitive potassium (K(ATP)) channels. K(ATP) channel expression has a significant physiologic impact on action potential duration shortening and myocardial energy consumption in response to physiologic heart rate...
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