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Article

Functional cross-talk between phosphorylation and disease-causing mutations in the cardiac sodium channel Nav1.5.

Proceedings of the National Academy of Sciences of the United States of America - 17 Aug 2021

Galleano Iacopo, Harms Hendrik, Choudhury Koushik, Khoo Keith, Delemotte Lucie, Pless Stephan Alexander

Abstract excerpt

The voltage-gated sodium channel Nav1.5 initiates the cardiac action potential. Alterations of its activation and inactivation properties due to mutations can cause severe, life-threatening arrhythmias. Yet despite intensive research efforts, many functional aspects of this cardiac channel remain poorly understood. For instance, Nav1.5 undergoes extensive posttranslational modification in vivo, but the functional...

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Identifiers

PMID: 34373326
DOI: 10.1073/pnas.2025320118
PMCID: PMC8379932

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