Article
Conduction abnormality in gap junction protein connexin45-deficient embryonic stem cell-derived cardiac myocytes.
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology - 1 Oct 2004
Egashira Katsuko, Nishii Kiyomasa, Nakamura Kei-Ichiro, Kumai Madoka, Morimoto Sachio, Shibata Yosaburo
Abstract excerpt
In early-stage heart, the cardiac impulse does not propagate through the specialized conduction system but spreads from myocyte to myocyte. We hypothesized that the gap junction protein connexin45 (Cx45) regulates early-stage contractions, because it is the only gap junction protein described in early hearts. Cx45-deficient (Cx45(-/-)) mice die of heart failure, concomitantly displaying other complex defects in...
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