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Article

A 14-3-3 mode-1 binding motif initiates gap junction internalization during acute cardiac ischemia.

Traffic (Copenhagen, Denmark) - 1 Jun 2014

Smyth James W, Zhang Shan-Shan, Sanchez Jose M, Lamouille Samy, Vogan Jacob M, Hesketh Geoffrey G, Hong Tingting, Tomaselli Gordon F, Shaw Robin M

Abstract excerpt

Altered phosphorylation and trafficking of connexin 43 (Cx43) during acute ischemia contributes to arrhythmogenic gap junction remodeling, yet the critical sequence and accessory proteins necessary for Cx43 internalization remain unresolved. 14-3-3 proteins can regulate protein trafficking, and a 14-3-3 mode-1 binding motif is activated upon phosphorylation of Ser373 of the Cx43 C-terminus. We hypothesized that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24612377
DOI: 10.1111/tra.12169
PMCID: PMC4278178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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A 14-3-3 mode-1 binding motif initiates gap junction internalization during acute cardiac ischemia.PMID 24612377Read ↗

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